CBD (cannabidiol) Learning Resources on the Treatment of Cancer

General

• Cannabidiol as potential anticancer drug (PubMed)
• Cannabidiol inhibits angiogenesis by multiple mechanisms (PubMed)
• The inhibitory effects of cannabidiol on systemic malignant tumors (PubMed)
• Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1 (PubMed)
• Marijuana fights cancer and helps manage side effects (Daily Beast)

Lung

• Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1C (PubMed)
• COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells (PubMed)
• Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of cannabidiol on human lung cancer cells (PubMed)
• Media ignored expert’s shocking findings that marijuana helps prevent lung cancer(O’Shaughnessy’s)

Prostate / Colon

• Towards the use of non-psychoactive cannabinoids for prostate cancer (PubMed)
• In Vitro Anticancer Activity of Plant-Derived Cannabidiol on Prostate Cancer Cell Lines (Scirp.org)
• Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent (PubMed)
• Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer (PubMed)
• Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol (PubMed)

Breast

• Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma (PubMed)
• Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy (PubMed)
• Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis (PubMed)
• Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells (PubMed)
• Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration (PubMed)

Glioblastoma / Brain

• Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival (PubMed)
• Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines(PubMed)
• Systematic review of the literature on clinical and experimental trials on the antitumor effects of cannabinoids in gliomas (PubMed)
• Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism (PubMed)
• Id-1 is a key transcriptional regulator of glioblastoma aggressiveness and a novel therapeutic target (PubMed)
• Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents (PubMed)
• Cannabidiol, a non-psychoactive cannabinoid compound, inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect (PubMed)
• Local delivery of cannabinoid-loaded microparticles inhibits tumor growth in a murine xenograft model of glioblastoma multiforme (PubMed)

Leukemia

• Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression (PubMed)
• Cannabidiol-Induced Apoptosis in Human Leukemia Cells (PubMed)

Skin

• Anticancer activity of anandamide in human cutaneous melanoma cells (PubMed)

Kaposi Sarcoma

• Cannabidiol inhibits growth and induces programmed cell death in kaposi sarcoma-associated herpes virus-infected endothelium (PubMed)

Endocrine

• Endocannabinoids in endocrine and related tumours (PubMed)
• A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells (PubMed)

Bladder

• TRPV2 activation induces apoptotic cell death in human T24 bladder cancer cells: a potential therapeutic target for bladder cancer (PubMed)

Pain

• Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain (PubMed)
• Nabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: a randomized, placebo-controlled, graded-dose trial (PubMed)
• Marijuana extract helps prevent chemo pain (UPI)